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Giving an I.V. bolus injection

When giving an I.V. bolus injection, keep these considerations in mind:

Drug tolerance declines in patients with decreased cardiac output, diminished urine output, pulmonary congestion, or systemic edema. To compensate, dilute the prescribed drug more than usual and administer it at a slower rate.
Don't give a drug by I.V. bolus injection if you need to dilute it in a large-volume parenteral solution before it enters the bloodstream.
Avoid using an I.V. bolus injection whenever the rapid administration of a drug, such as potassium chloride, could cause life-threatening complications.